Our flexible, swift approach to peptide synthesis projects is made possible by investment in our solid-phase peptide synthesis (SPPS) capabilities. This enables us to provide you with a seamless custom peptide synthesis service.
Our Custom Peptide Synthesis Services
From start to finish, our peptide chemists will work with you to ensure you get the most out of your peptide project.
Our experienced peptide chemists use their expertise to design the most efficient route for your peptide, as well as selecting the most appropriate resin for achieving your goals. By taking responsibility for ordering in all the chemicals required our team can get your project off to a quick and efficient start.
Learn about our recent peptide projects from our case studies:
Solid-phase Peptide Synthesis
Charnwood Discovery offers both fully automated as well as manual solid-phase peptide (SPPS) synthesis for our clients, utilizing:
- Automated SPPS: on our multi-channel PurePep® Chorus peptide synthesizer
- Manual SPPS: with our peptide shakers
Depending on the synthetic sequence and your downstream requirements, we can selectively remove your peptide from the resin in either the protected (facilitating additional synthesis or modifications) or fully deprotected.
Additionally, we can also complete late-stage modifications either “on” or “off” the resin, such as cyclization or fluorescent tagging. Following this, our in-house purification team will carry out any necessary purification work with a specialized method, enabling high throughput methodologies.
Peptides and Peptoids in Drug Discovery
With peptide and peptoid based drugs continuing to gain prominence understanding the most efficient way to synthesize and test them is key to success in drug discovery programs. Our integrated teams have extensive experience synthesizing peptoids via an automated (and manual as required) sub-monomer approach enabling access to a wide range of N-alkylated peptides (peptoids) rapidly.
In our free to download webinar learn about the recent advances in peptide drug development. Focusing on cyclic peptides and the challenges involved in their synthesis, handling, and applications.
Our Capabilities
Our PurePep Chorus is both Fmoc and Boc compatible, complementing our manual SPPS equipment (Kamush LP360AMP) with the following functionality:
- Four reactor slots all of which can be heated
- 27 amino acid bottles and six slots for single use amino acids
- Eight solvent / reagent bottles which enables us to access significant complexity
- Fully automated synthesis
- Compatible with a wide range of resins
- Option to synthesize unnatural peptides
Purification and Analysis
Our dedicated team in purification and analytical chemistry actively utilizes their experience to expedite the rapid turnaround of compounds, enabling high throughput projects. This approach frees up the chemists on the project to concentrate on synthesizing new targets without being distracted by complicated purification work.
Our open access UPLC-MS system, equipped with UV, MS and ELS detectors, enables us to tailor our analytical methods for each project. Therefore, allowing the team to optimize the purity profiles of their reactions, and track the different components of their reactions across a range of different molecule types. This results in higher levels of understanding and great confidence in quality.
