Cyclic Peptide Synthesis for Drug Discovery: Uses, Benefits and Challenges – Webinar

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Charnwood Discovery and Gyros Protein Technologies teamed up to produce a live webinar which you can access here on-demand at a time to suit you.

Principal Scientist, Dr James Krupa uses his expertise to explore the complexities of cyclic peptide synthesis. 

Abstract

In 2023, peptide-based drugs continued to gain prominence. Three out of six new peptide drug approvals were for cyclic peptides due to their favorable drug properties, such as cell permeability, proteolytic stability and binding kinetics. Cyclic peptides, however, often result in challenging projects due to the difficulty of synthesis or time constraints.

This webinar focuses on the recent advances in peptide drug development. Specifically, it focuses on cyclic peptides and the challenges involved in their manufacturing, handling and applications from a Contract Research Organisation’s (CRO) perspective.

Experts will explore the nuances of cyclic peptide synthesis and how a we leverage state-of-the-art technology to enhance its capabilities to meet complex project requirements. Attendees will learn about the synthesis and cyclization of peptides, potential issues with ring strain and what to look for when working with unstable cyclic peptides. In addition approaches to understanding the structure–activity relationship (SAR) of a cyclic peptide and some issues in drug discovery will also be covered.

This session is ideal for anyone interested in cyclic peptide synthesis and its role in drug discovery.

About the Presenter

Dr James Krupa

Dr James Krupa

Principal Research Scientist

Dr James Krupa is a Principal Research Scientist at Charnwood Discovery. His career has been split between organic chemistry and peptide synthesis. It began in the School of Chemistry at the University of Nottingham in the UK, where James earned his PhD in 2015 for his work on the development of fluorine MRI probes for imaging protease activity. 

James then went on to begin his industrial career, first in peptide chemistry at Pepceuticals, followed by a move to Charnwood Discovery. He then went back into academia for a year with a Postdoc at the School of Medicine, University of Nottingham, developing Xenon MRI agents. In 2018, James returned to Charnwood Discovery where he leads a team of synthetic chemists working to meet client needs.

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At Charnwood Discovery, our commitment to advancing peptide synthesis projects is exemplified by our robust solid-phase peptide synthesis (SPPS) capabilities. We offer a flexible, efficient approach to meet the diverse needs of discovery projects, backed by significant investments in state-of-the-art technology and expert chemists.

Explore our case studies to see examples of our recent peptide projects:

Alternatively, you can find out more about our capabilities from our peptide synthesis FAQs. 

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