Pharmacokinetics & Bioanalysis

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Charnwood Discovery’s pharmacokinetics (PK) and bioanalysis services are run by a team of experts working with clients on a wide range of compound classes. Consequently, this breadth of experience helps clients to rapidly identify the best drug candidates and advance their projects.

Our bioanalytics service provides a swift turn around for non-GLP results, allowing you to move forward with your project. Additionally, if your project requires more complex problem solving, our expert team have the capability to understand and resolve your bioanalytical issues.

Our Bioanalytical Services

We provide standalone bioanalytical services for samples generated from in vitro studies or in a range of matrices and tissues from in vivo studies.

Alternatively, using our trusted, UK based in-life providers, we can:

  • Plan and conduct pharmacokinetic (PK) studies
  • Carry out the bioanalysis
  • Generate the relevant PK parameters

PK studies allow determination of in vivo exposure, and an understanding of whether a compound is behaving as expected based on in vitro screening data.

Bioanalysis & Pharmacokinetics PK


For quantitative bioanalysis, a matrix-matched standard curve and quality control (QC) samples are prepared from two separate weighings. These standard and QC samples bracket the in vivo study samples during analysis and cover the expected range of analyte concentrations.

Compound concentrations are measured in the samples, and, where required, non-compartmental analysis can be carried out to generate PK parameters using specialist software such as Phoenix WinNonlinTM

Report Provided

Our standard reporting format includes:

  • Summary table in excel
  • Details of LC-MS method
  • Word reports upon request at an additional cost

Data Quality Assured

Bioanalysis & Bioanalytical Services

We use a Thermo ScientificTM Exploris 120 Quadrupole Orbitrap mass spectrometer (MS) with a Thermo ScientificTM Vanquish Horizon ultra-high performance liquid chromatography (UHPLC) system.

The Exploris is a sensitive, high-resolution instrument capable of generating accurate mass data for quantitative bioanalysis.

It provides the specificity and selectivity to allow the generation of data using full scan MS. This enables our bioanalytical services to access a wide range of compound classes from small polar molecules to more conventional drug-like molecules and peptides.