Drug discovery success is contingent on a number of factors with ADME / DMPK playing a vital role in providing the data and analytical insights to support time and cost-efficient research.
For a candidate compound to ultimately progress to market, there are a number of desirable ‘drug-like’ properties that first need to be optimized.
ADME / DMPK Services
A key benefit of employing ADME / DMPK services early in a project, such as during hit to lead, is that the best molecule is optimized rather than progressing based on potency alone. Clients subsequently benefit from a reduced time for lead optimization due to the starting molecule having more ‘drug-like’ characteristics.
As a result of this work researchers are armed with key information during the design-make-test-analyze cycle and beyond.
Charnwood Discovery offers the following ADME / DMPK services:
- Physicochemical compound profiling
- DMPK assay development and validation
- Routine DMPK screening
- In vivo PK and bioanalysis
- Metabolite identification (Met ID)
Our Approach
Our ADME/ DMPK experts can work stand-alone, or as part of an integrated project with our chemists and bioscience team to deliver candidates.
Our growing team also offers expert DMPK project management. Working in collaboration with clients, our scientists provide advice and guidance on the best approach to take for each project.
Project management and support is flexible and allows a tailored approach to clients’ requirements. For example, we encourage clients to speak to us about how our routine assays can be adapted to answer specific questions.
In addition, we continue to invest in the latest technology including:
- High-resolution accurate-mass LC-MS instruments
- Nexcelom K2 Cellometer® Advanced Cell Counter
In-House Capabilities
We work hand-in-hand with our chemistry and bioscience teams to share expert knowledge of different target classes and therapeutic areas.
A key strength is the speed at which we bring our co-located scientists together to discuss the best approach to a project. This ensures that projects are delivered both to time and budget.
Our core capabilities, in addition to DMPK services, are:
