Drug discovery success is contingent on a number of factors with ADME / DMPK services playing a vital role in providing the data and analytical insights to support time and cost-efficient research.
For a candidate compound to ultimately progress to market, there are a number of desirable ‘drug-like’ properties that first need to be optimized.
ADME / DMPK Services
A key benefit of employing ADME / DMPK services early in a project, such as during hit to lead, is that the best molecule is optimized rather than progressing based on potency alone. Clients subsequently benefit from a reduced time for lead optimization due to the starting molecule having more ‘drug-like’ characteristics.
As a result of this work researchers are armed with key information during the design-make-test-analyze cycle and beyond.
Charnwood Discovery offers the following ADME / DMPK services:
- Physicochemical compound profiling
- DMPK assay development and validation
- Routine DMPK screening
- In vivo PK and bioanalysis
- Metabolite identification (Met ID)
Our Approach
Charnwood Discovery’s ADME/ DMPK experts can work stand-alone, or as part of an integrated project with our chemists and bioscience team to deliver candidates.
Our growing team provides expert DMPK project management. Collaborating with clients, our scientists offer advice and guidance on the optimal approach for each project.
The flexibility of project management and support allows for a tailored approach to clients’ requirements. For instance, we encourage clients to engage with us regarding how our routine assays can be adapted to address specific questions.
In addition, we continue to invest in the latest technology including:
- High-resolution accurate-mass LC-MS instruments
- Nexcelom K2 Cellometer® Advanced Cell Counter
In-House Capabilities
We work hand-in-hand with our chemistry and bioscience teams to share expert knowledge of different target classes and therapeutic areas.
A key strength is the speed at which we bring our co-located scientists together to discuss the best approach to a project. This ensures that projects are delivered both to time and budget.
Our core capabilities, in addition to DMPK services, are:
