Use of the Thermo Scientific™ Vanquish Horizon UHPLC and Orbitrap Exploris™ 120 in Discovery DMPK

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Discover how the latest advances in high-resolution mass spectrometry (HRMS) are transforming discovery Drug Metabolism and Pharmacokinetics (discovery DMPK). This poster highlights the shift from traditional triple quadrupole systems to cutting-edge HRMS instruments, like the Thermo Scientific™ Orbitrap Exploris™ 120, for more informative data acquisition.

Find out how we:

  • Achieve reliable sensitivity and excellent dynamic range in full scan analysis with high resolution and accurate mass capability.
  • Save significant time by eliminating the need for MS/MS method development.
  • Handle challenging compounds, including PROTACs and peptides, with ease.
  • Identify metabolites and potential issues in a single analysis.

Learn how the Orbitrap Exploris™ 120, paired with the Thermo Scientific™ Vanquish UHPLC system, delivers robust, sensitive, and reproducible data for both in vitro and in vivo discovery DMPK assays.

Download your poster here

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