The development of a robust screening cascade is key part of the drug discovery process. During the development of small molecule therapeutics a good screening cascade should be able to efficiently identify compounds that engage with the target, determine the selectivity and demonstrate activity in function and phenotypic assays.
Molecular glues are an exciting area of targeted protein degradation, they have the capability of stabilizing the interaction between E3 ligase and the target protein while maintaining a low molecular weight.
